Endothelial glycocalyx degradation is associated with early organ impairment in polytrauma patients

Abstract Background Endothelial glycocalyx (EG) abnormal degradation were widely found in critical illness. However, data of EG multiple traumas is limited. We performed a study to assess the and correlation between organ functions polytrauma patients. Methods A prospective observational was conducted enroll health participants (control group) patients (trauma at University affiliated hospital Feb 2020 Oct 2020. Syndecan1 (SDC1) heparin sulfate (HS) detected serum sample both groups. In trauma group, injury severity scores (ISS) sequential failure assessments (SOFA) calculated. Occurrences acute kidney (AKI), trauma-induced coagulopathy (TIC) within 48 h 28-day all-cause mortality group recorded. Serum SDC1 HS levels compared two Correlations SDC1/HS indicators systems analyzed. ROC analyses predictive value for AKI, TIC h, group. Results There 45 15 healthy collected, totally. significantly higher than control (69.39 [54.18–130.80] vs. 24.15 [13.89–32.36], 38.92 [30.47–67.96] 15.55 [11.89–23.24], P < 0.001, respectively). Trauma divided into high low according median. High had more severe ISS, SOFA scores, worse (respiratory, kidney, coagulation metabolic system), incidence hypothermia, acidosis shock. The area under receiver operator characteristic curves (AUC) predict occurrence 0.838 (95% CI : 0.720–0.957), 0.700 0.514–0.885) 0.764 0.543–0.984), respectively. Conclusions elevated patients, correlated with impaired respiratory, early stage. valuable indicator onset TIC,